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Hypoxia-induced mROS inhibits HIF-1 hydroxylation and upregulates the HIF-1/PDK1&PDK2/p-PDH-E1 axis, enhancing lactate production and histone lactylation

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Ferroptosis has also been indicated to be involved in APAP hepatotoxicity (Yamada et al., 2020), which is not supported by the data obtained under pathophysiologically relevant condition (Jaeschke et al., 2021

Becaplermin is one of the only growth factors actually approved for wound healing